El-Sayed M. El-Sayed, Ahmed M. Mansour and Mohamad Y. Ghobara
ABSTRACT
This study aimed to evaluate the possible protective effect of lycopene against cisplatin-induced nephrotoxicity in male rats. A single dose (6 mg/kg) of intraperitoneal (ip) injection of cisplatin caused significant increase in serum urea, creatinine, TNF-α, caspase-3 and lipid peroxides measured as malondialdehyde (MDA), with significant decreases in serum albumin, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) as compared with the control group. Lycopene and vitamin E (a standard reference drug) were given orally (po) at doses of 5mg & 1g/kg, respectively for 14 days before cisplatin and 7 days after cisplatin injection produced significant decrease in serum levels of urea, creatinine and TNF-α as well as kidney contents of MDA and caspase-3 with marked increase in serum albumin and GSH content and activities of enzymes (SOD and CAT). In conclusion, lycopene afforded protection against cisplatin-induced nephrotoxicity through its antioxidant, antiapoptotic and anti-inflammatory activities.
Keywords: Antiapoptotic, Antioxidant, Cisplatin, Lycopene, Nephrotoxicity.