In silico molecular docking and ADME-toxicity studies on Berberine derivatives against NS3 protein of Zika virus

Amit Mohan and Neetu Kirti ABSTRACT Zika virus causes large epidemics in worldwide. Its infection causes a serious birth defect during pregnancy. In this work, we screened berberine derivatives from PubChem compound database and docked with NS3 protein of Zika virus. Among docked compounds, we got one best-predicted compound CID 52948350 having binding affinity -9.44…

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INTERACTION STUDIES TO EVALUATE PYRIMETHAMINE DERIVATIVES AS INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE

Indra Vikram Singh, , Anup Kumar  The rapid emergence of Plasmodium falciparum malaria resistant to currently available antifolate antimalarial drugs has added a further serious concern, making the provision of malarial treatment increasingly difficult and costly. So, there is an urgent need to search for new antimalarials which are both effective and cheap, to combat…

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A REVIEW ON: SUSTAINED RELEASE TECHNOLOGY

M.M. GUPTA, RAY BRIJESH.  All drug delivery systems, oral drug delivery remain the most preferred option for administration for various drugs. Sustained Release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. The basic rationale of sustained drug…

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SIMULTANEOUS ESTIMATION OF PIPERINE, QUERCETIN, AND CURCUMIN IN A MIXTURE USING U.V-VISIBLE SPECTROPHOTOMETER AND METHOD VALIDATION.

Ginpreet. Aneja , Urja. Dave and K. Vadodaria  U.V Spectrophotometric method have been widely employed in determination of individual components in a mixture or fixed dose combination. For the ternary mixture containing Quercetin, Curcumin and Piperine (Anti-inflammatory action) no spectrophotometric method for simultaneous evaluation has been reported so far. Thus our aim is to develop…

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DESIGNING & DEVELOPMENT OF SPHERICAL AGGLOMERATES OF IBUPROFEN-PARACETAMOL BLEND FOR IMPROVED TABLETING AND DISSOLUTION

Pavitra Solanki, Anoop Kumar, Abhinav Garg, Pankaj Sharma , Satyavir Singh  Blends of paracetamol and ibuprofen (5:2) incorporating sodium starch glycolate as disintegrants was spherically agglomerated (SAPI) in benzene-water system.  SAPI were agglomerated using aqueous hydroxypropylmethylcellulose (HPMC) solution as bridging liquid. Agglomeration process was optimized for several parameters like speed and duration of agitation, volume…

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NOVEL APPROACHES FOR INSULIN DELIVERY: CURRENT STATUS

 A novel series of 3-hydroxy-2-(substituted phenyl)-4H-chromen-4-one derivatives(IIa-d) were synthesized by Algar-Flym-Oyamada reactions, o-hydroxy acetophenone and substituted aromatic aldehyde were reacted in ethanol followed by addition of sodium hydroxide (40%) which leads to the formation of substituted chalcone (Ia-d). synthesized compounds (Ia-d) were further reacted with ethanol, sodium hydroxide and hydrogen peroxide for 2-3 hours at room temperature which give the titled compound 3-hydroxy-2-(substituted phenyl)-4H-chromen-4-one(IIa-d). The structures of all these compounds have been established on the basis of analytical and spectral data. Synthesized compounds were characterized by their IR, 1H-NMR, elemental and mass spectroscopic data.  Synthesized compounds were then screened for anti-oxidant, anti-inflammatory and ulcerogenic activity. The anti-oxidant activity was performed by DPPH free radical scavenging method using ascorbic acid as standard and compound IIa, IIc and IId showed significant free radical scavenging activity. The anti-inflammatory activity was performed using carrageenan induced rat paw edema method and compound IIa and IId showed most significant anti-inflammatory activity. The acute ulcerogenic activity was performed on albino-wistar rats by ceoli et al method using aspirin as standard drug.  Among the synthesized compounds only IId was found to have significant antioxidant and potential anti-inflammatory activity with no ulcerogenic effect. Among the synthesized compounds significant activity were shown by the compounds having substitution such as- 4-nitro, 3-nitro and 2, 6-dichloro respectively on the phenyl ring of the flavonol nucleus.
Keywords: Antioxidant, anti-inflammatory, flavonol, ulcerogenic.
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NOVEL APPROACHES FOR INSULIN DELIVERY: CURRENT STATUS

Varshney H. M., Rajnish kumar, Shailender Mohan  Diabetes mellitus is a serious pathologic condition which is responsible for major healthcare problems worldwide and costing billions of dollars annually. Insulin replacement therapy has been used in the clinical management of diabetes mellitus for more than 84 years. Insulin has remained indispensable in the management of diabetes mellitus since its discovery in 1921.…

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FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE GASTRORETENTIVE TABLETS OF METFORMIN HYDROCHLORIDE

Ritesh Kumar, Amrish Chandra, Seema Garg  In the present study hydrophilic gelling polymer based gastroretentive (floating) tablets of metformin hydrochloride were formulated and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an…

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BIO SYNTHESIS AND ANTHELMINTIC ACTIVITY OF SILVER NANOPARTICLES USING AQUEOUS EXTRACT OF SARACA INDICA LEAVES

Seema Garg, Amrish Chandra ABSTRACT Present study was conducted to know the anthelmintic activity of colloidal solution of silver nanoparticles using Saraca indica leaves extract. The bio-synthesized nanoparticles were characterized using UV-visible (UV-vis) spectrophotometer, transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infra-red (FTIR) spectrometry. The nanoparticles were found to be spherical in…

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