3-HYDROXY-2-(SUBSTITUTED PHENYL)-4H-CHROMEN-4-ONE DERIVATIVES- SYNTHESIS, SPECTRAL CHARACTERIZATION AND PHARMACOLOGICAL SCREENING

SAKSHI GUPTA, N.KUMAR, S.KUMAR, R.DUDHE, P. K. SHARMA A novel series of 3-hydroxy-2-(substituted phenyl)-4H-chromen-4-one derivatives(IIa-d) were synthesized by Algar-Flym-Oyamada reactions, o-hydroxy acetophenone and substituted aromatic aldehyde were reacted in ethanol followed by addition of sodium hydroxide (40%) which leads to the formation of substituted chalcone (Ia-d). synthesized compounds (Ia-d) were further reacted with ethanol, sodium…

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COMPARATIVE STUDY ON ISOLATION AND BIOCHEMICAL CHARACTERIZATION OF STAPHYLOCOCCUS AUREUS FROM MILK AND MILK PRODUCTS OF MATHURA

SHARMA BRIJESH. and VERMA BHUVNESHWARI. ABSTRACTThis investigation presents comparative data on detection of Staphylococcus aureus in milk products of Mathura & nearby region. A total of 30  samples including 5 each from milk vendors, household milk, dairy farm, Gaushala, butter and Dahi  were tested for the presence of Staphylococcus aureus and  identified by isolation using…

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SOLUBILITY ENHANCEMENT OF POORLY HYDROPHILIC DRUGS BY USING DIFFERENT NEWER TECHNIQUES: A REVIEW

Varshney, H. M. , Chatterjee, A. ABSTRACTTherapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules. In case of the oral administration solubility is one of the important parameter for achieving desired concentration of drug in systemic circulation for pharmacological response to be shown. Currently, 40% of the…

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STUDY OF HALOGEN SUBSTITUENT ON DOCKING AND 3D QSAR PROPERTIES OF ARYL SUBSTITUTED THIOSEMICARBAZONES AS ANTICONVULSANT

Yogesh Singh, Jainendra Jain , Partha Chowdhury, Lalit Nainwal ABSTRACTGamma amino butyric acid (GABA) is a major inhibitory neurotransmitter mainly responsible for action of almost all antiepileptic compounds, Gamma amino butyrate amine transferase (GABA-AT) is one of the most important targets in the design and discovery of successful anti-epileptics. Lysine 329A and Arginine 192A are…

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RELATIONSHIP BETWEEN INSULIN RESISTANCE AND ASSOCIATED DISEASES: AN OVERVIEW WITH ITS MECHANISM

Shanti Bhushan Mishra ABSTRACTInsulin resistance is a common feature in obesity and possibly can lead to further disorders metabolic syndrome like type 2 diabetes mellitus. Lipodystrophies on the other hand are associated with decreased adipose mass but are, again, characterized by insulin resistance. Hyperinsulinaemia, which accompanies IR, is thought to play an important role in…

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ROLE OF NANOTECHNOLOGY IN CANCER THERAPY AND DIAGNOSIS

Anupama Bhadauria, Rakesh P. Patel ABSTRACT:In the recent times nanotechnological innovations have been applied extensively in finding solutions to problems encountered during conventional cancer therapy and diagnosis- mainly catering to drug targeting and minimizing concomitant adverse effects. From the first studies on liposome-encapsulated drug nanoparticles, progressing through PEGylation to incorporation of biomarkers on the surface,…

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PHARMACOLOGICAL EVALUATION OF SOME 1-(SUBSTITUTEDBENZYLIDENE)-4-(4-(2-(METHYL/PHENYL)-4-OXOQUINAZOLIN-3(4H)-YL)PHENYL)SEMICARBAZIDE DERIVATIVES

Govindaraj Saravanan, Veerachamy Alagarsamy ABSTRACTA series of 1-(substitutedbenzylidene)-4-(4-(2-(methyl/phenyl)-4-oxoquinazolin- 3(4H)-yl)phenyl) semicarbazide derivatives were synthesized and evaluated for analgesic, anti-inflammatory and ulcerogenic activities. The title compounds were screened for analgesic activity by tail‒flick technique using Wistar albino mice orally at two dose levels i.e. 10 and 20 mg/kg. The carrageenan-induced foot paw edema test was performed for…

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