INHIBITION OF AN EPIGENETIC MODULATOR, HISTONE DEACETYLASE BY PEITC IN BREAST CANCER – A DETAILED MECHANISTIC APPROACH

MADHUMITA ROY, SUTAPA MUKHERJEE, JAYDIP BISWAS ABSTRACTHistone deacetylases (HDACs) are enzymes that modify the architecture of chromatin leading to decreased gene expression, the effect of which may be reversed by HDAC inhibition. The balance between acetylation and deacetylation of histones play a key role in many biological events including regulation of cell proliferation and cancer.…

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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF 2-(5-MERCAPTO-3-SUBSITUTED-1,5-DIHYDRO-[1,2,4]TRIAZOLE-4-YL)-ISOINDOLE-1, 3-DIONE

Parjanya Kumar Shukla, Neetu Soni, Abhinav Jha ABSTRACTNitrogen containing heterocycles have got special attention in Pharmaceutical Chemistry due to their excellent Medicinal potential.  The 1,2,4-triazole nucleus is associated with diverse pharmacological activities such as antibacterial, antifungal, hypoglycemic, antihypertensive, analgesic, anti-inflammatory, anti-tumor, anti-viral, urease inhibition and many other  properties. The increasing importance of 1,2,4-Triazoles as potent…

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EVALUATION OF EUKARYOTIC GENE PREDICTION PROGRAMMS

DIVYA SINGHAL, POOJA SHARMA, MOKSHA SHANDILYA ABSTRACTGene finding typically refers to the area of computational biology that is concern with algorithmically identifying stretches of sequence, usually genomic DNA, that are biologically functional. This specially includes protein coding genes but may also include other functional elements such as RNA gene and regulatory regions. Gene finding is…

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DESIGN, DEVELOPMENT, PHYSICOCHEMICAL CHARACTERISATIONS AND IN VITRO EVALUATION OF KETOPROFEN MICROSPHERES

Varshney H.M., Tanwar Y.S., Chauhan B.S., Sharma P.K. ABSTRACTBackground and the purpose of the study: Generally, drug release from biodegradable polymer depends upon the drug solubility in the polymer, the chemical composition of the polymer and drug particle size. Ketoprofen exhibits short half-life, poor compressibility, caking tendency, gastrointestinal irritation & ulcerogenic effect. Hence, it is…

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DESIGN AND EVALUATION OF INSULIN LOADED BIO-FILMS FOR TRANS SOFT-PALATAL TO BRAIN DELIVERY

N.V.Satheesh Madhav, Pranshu Tangri ABSTRACT:The current objective of our study was the formulation and evaluation of insulin loaded trans-soft palatal bio-films for treating alzhiemer’s disease. A novel bio-film former was isolated from the fruit pulp of Artocarpus heterophyllus by our previously published method. The bio-films were aimed at delivery through the soft palate for brain…

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RECENT ADVANCEMENT IN DEVELOPMENT OF DRUG ELUTING STENTS DELIVERY SYSTEM

MUKUND LATA BHARTI ABSTRACTCardiovascular diseases are one of the major causes of death in industrially developed countries.  In particular occlusive pathologies of coronary and peripheral arteries are the third cause of  death in these countries. The recent introduction of drug eluting stents (DES) technology  contributes a major advancement in the treatment of obstructive coronary –…

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IMMUNOMODULATORY ACTIVITY OF LACTOBACILLUS SPOROGENES

V BABAR , R THOMAS , M. BHASKAR ABSTRACTThe present study was undertaken to explore the immunomodulatory activity of probiotic strain Lactobacillus sporogenes on total leukocyte count, differential leukocyte count, neutrophil adhesion test, humoral response to BCG vaccine, delayed-type hypersensitivity and phagocytic activity.Pre-treatment with probiotic evoked a significant increase in total leukocyte count and per-cent…

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DOCOSAHEXAENOIC ACID: WONDER DIETARY SUPPLEMENT

JYOTI KUMARI, S. YADAV, V. SHARMA ABSTRACTDocosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain and retina and is manufactured internally by α-linolenic acid. Although α-linolenic acid (ALA) does convert to DHA in humans, the process is inefficient and very limited even in healthy individuals. Most…

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CEREBRAL PALSY: A MINI REVIEW

AMRITA KUMARI, S. YADAV ABSTRACT:Cerebral palsy is non-progressive motor disability which is caused by abnormal development or damage in one or more parts of the brain that control muscle tone and motor activity (movement). This lesion is static, the manifestation of the disorder and the needs of the individual changes with age. It may involve…

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BIOSIMILARS OR “FOLLOW ON BIOLOGICS” – A REVOLUTIONARY CHANGE IN BIOTECHNOLOGY

NEHA MISHRA, S. YADAV ABSTRACT Biosimilars or “Follow-on-Biologic” defined as biologic medicinal products comparable in quality safety and efficacy to reference products, follow the independent regulatory pathway in the EU for marketing authorizations after the patent expirations of the reference products. Also these are similar to, but not the same as, innovator biologics which are…

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