In silico molecular docking and ADME-toxicity studies on Quinacrine derivatives against NS5-methyltransferase of dengue virus

Amit Mohan and Neetu Kirti ABSTRACT Dengue is a standout amongst the most vital mosquito-borne viral infections on the planet, and is endemic in roughly 120 nations. Dengue fever is showed as a weakening infection in more seasoned youngsters, youths, and grown-ups. In this work, we screened Quinacrine derivatives from PubChem compound database and docked…

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TRANSDERMAL DRUG DELIVERY SYSTEM: A REVIEW

Rohit Tiwari, Manish Jaimini, Shailender Mohan, Sanjay Sharma ABSTRACT Transdermal drug delivery has made an important contribution to medical practice, but it has yet to fully achieve its potential as an alternative to the oral delivery and hypodermic injections. An advantage of a transdermal drug delivery route over other types of delivery systems such as…

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DESVENLAFAXINE INDUCED CONGENITAL MALFORMATIONS IN SWISS ALBINO MICE

Amrita Kumari, Mandavi Singh, Anand Mishra, Shamsher Shrestha, Uttam Shrestha ABSTRACT Desvenlafaxine is a bicyclic phenylethylamine compound which inhibit neuronal uptake of 5-HT and norepinephrine,with significantly lower in vitro affinity for norepinephrine. This drug is used for the treatment of depressive disorder. In the present study, desvenlafaxine is administered by oral gavage at the dose…

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INVITRO PRODUCTION OF MONOCLONAL ANTIBIOTICS AS AN ALTERNATIVE OF INVIVO PRODUCTION IN RODENT

Gautam Arora, Amrish Chandra ABSTRACT Many areas of biomedical research focus on the study of human-specific diseases and medical concerns for which induced animal models are seldom, if ever, appropriate or scientifically relevant. This largely reflects obvious species-specific differences in anatomy, biochemistry, physiology, pharmacokinetics, and toxic responses. Use of replacement methods, especially incorporating human cells…

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MEDICO SOCIAL PROFILE OF SCHOOL DROPOUTS FROM URBAN SLUM

Vaishali Raje, Vinayak Raje ABSTRACT Introduction: India has taken 60 years to put Indias literacy rate to 66% since independence but still we are a country of 380 million illiterates. School dropout is a major social pathology which lands up children in social problems like juvenile delinquency, unemployment and poverty. School dropouts synergizes with poverty,…

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DEVELOPMENT AND EVALUATION OF ANTI-DIABETIC POLYHERBAL FORMULATION ON ALLOXAN INDUCED RATS

Rajput Rekha, Chandra Amrish The polyherbal anti-diabetic formulation is prepared in suspension form by mixing the petroleum ether and chloroform extracts of five medicinal plants which are indigenous in India with other excipients because plants are a potential source of anti-diabetic drugs. The anti-diabetic effect of prepared suspension was evaluated at two different doses which…

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ANTIBIOGRAMS OF COMMUNITY-ACQUIRED UROPATHOGENS FROM A SECONDARY CARE RURAL HOSPITAL IN SOUTHERN INDIA

Suzanne Sonya Cherian, John Jacob, Rakesh PS, Immanuel R ABSTRACT Introduction: Antimicrobial resistance to uropathogens is a growing problem and a cause of major concern in many countries including India. The current study was done with the objective to study the antibiotic sensitivity pattern of pathogens causing Urinary Tract Infections (UTIs) in a secondary care…

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EFFECT OF CIGARETTE SMOKING ON THYROID HORMONES IN SUDANESE SMOKERS

Yasir M.Ahmed, AbdElkarim A. Abdrabo Effect of cigarette smoking on serum thyroid hormones i.e. thyroxin (T3) and triiodothyronine (T4) and their regulatory hormone i.e. thyrotrophin (TSH) was evaluated in healthy smoker individuals and compared with non smoker individuals. Enzyme linked immunosorbant assay (ELISA) was used to estimate level of T3, T4 and TSH. The results…

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