PHARMACOKINETIC/PHARMACODYNAMIC (PK/PD) MODELING OF ANTI-INFLAMMATORY EFFECT OF MELOXICAM, A PREFERENTIAL CYCLOOXYGENASE-2 INHIBITOR, IN RATS

Dheeraj Gopu, Harish Kaushik K, Gomathi P Objective: To establish a suitable Pharmacokinetic / Pharmacodynamic (PK/PD) model for the meloxicams anti-inflammatory activity for predictions about efficacy, potency and sensitivity by using a complex indirect response model in the rat, where carrageenin used as a inflammogen. Methods: The rats were divided into different groups and received…

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