A STUDY ON ADHERENCE PATTERNS, TOXICITIES AND QUALITY OF LIFE OF PATIENTS WITH PROGRESSIVE ADULT MALIGNANCIES ON METRONOMIC CHEMOTHERAPY

Anita Ramesh, Suma Abhinaya, Likitha Chowdary, Mareneni Malathi, Sindhu Chowdary,Vanitha Rani N, Thennarasu P ABSTRACT Objective: This study was conducted to assess the medication adherence patterns, toxicities and the quality of life of the patients with progressive solid malignancies, receiving metronomic chemotherapy.  Materials and Methods: 51 patients of either sex, aged above 18 years, attending…

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AN IN VIVO STUDY OF THE IMPACT OF 4MT STATIC MAGNETIC FIELD TO MODIFY THE DIFFERENTIATION RATE OF RAT BONE MARROW STEM CELLS INTO PRIMORDIAL GERM CELLS

Fatemeh Javani Jouni, Jaber Zafari, Parviz Abdolmaleki ABSTRACT Primordial germ cell (PGC) transplantation has become an assay to estimate the potential of germ cell development and a tool to determine whether the somatic environment or the germ cells are responsible for disturbed fertility of some transgenic animals. This investigation was performed to evaluate the differentiation…

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EFFECT OF AN INTEGRATED APPROACH OF YOGA THERAPY ON QUALITY OF LIFE IN CORONARY ARTERY DISEASE PATIENTS

Asha Yadav, Savita Singh, KP Singh, Preeti Pai ABSTRACT Background & Objectives: Anxiety and stress aggravates ill health in coronary artery disease (CAD) patients and also reduces the efficacy of medical or surgical treatment. Only medical management is not sufficient in these patients, lifestyle modification is very important for such psychosomatic disorder. Overall quality of…

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IMPAIRED GLUCOSE TOLERANCE TEST IN BLOOD TRANSFUSION DEPENDENT BETA THALASSEMIC CHILDREN

Bablu Kumar Gaur, Sunita Koreti, G.Das ABSTRACT Impaired glucose tolerance and Serum ferritin level in transfusion-dependent β-thalassemic children was studied. Known case of beta Thalassemia major childrens being regularly transfused in Department of Pediatrics, Kamla Raja Hospital, Gwalior.  This study was done on 60 children between 3-17 years of age with β thalassemia major. Information…

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POLY(LACTIC-CO-GLYCOLIC ACID)-LOADED BOLDINE NANOPARTICLES ALLEVIATES CISPLATIN INDUCED HEPATOTOXICITY IN NORMAL LIVER CELLS IN VITRO VIA DNA TARGETING: DRUG-DNA INTERACTION

Jesmin Mondal, Ashis Kumar Panigrahi, Anisur Rahman Khuda-Bukhsh ABSTRACT Whether PLGA-loaded nano-Boldine (NBol) induces apoptosis and cell cycle arrest to alleviate cisplatin-induced toxicity preferentially in normal liver calls (WRL-68) primarily via DNA-targeting has been addressed in this study. Nano-encapsulation of Boldine (Bol) was accomplished by solvent displacement method.   Effects of Bol and NBol were…

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PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON ZINGIBER ZERUMBET HYDRO-ALCOHOLIC EXTRACT FOR ANTICONVULSANT ACTIVITY

Lincy Joseph, Mathew George, Sreelakshmi.R ABSTRACT Aim- The aim of this study is to evaluate anticonvulsant activity and to determine the Total flavonoid content (TFC), Total tannin, Total carbohydrates in hydroalcoholic extract of Z. zerumbet. Materials and methods- Plant materials are collected from puthuppally.Hydroalcoholic extract was screened for different phytochemical constituents. Acute toxicity studies are…

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HEPATOTOXIC EFFECT OF CHARACTERIZED SILVER NANOPARTICLE

Jyoti Prakash Pani, S .P .Mishra, R.S. More, Sanjay Singh, Royana Singh ABSTRACT Silver nanoparticles (NPs), is widely used in the manufacture of various types of consumer products.  It is widely applied in textile industries, optics, electronics, catalysis, magnetic and medical fields, which includes therapeutic and diagnostic. It has antibacterial and antifungal property. It belongs…

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COORDINATION BEHAVIOR OF 4-((3-CHLORO-2-METHYLPHENYL) AMINO)BENZOIC ACID TOWARDS CR(III) AND CU(II) IONS: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY

Monika Chaudhary, Mradula Mittal ABSTRACT Cr(III) and Cu(II) complexes (1–6) of general composition M(L1)X2 and M(L1)2 (M=Cr(III), Cu(II), X=Cl-1, NO3-1) with ligand 4-((3-chloro-2-methylphenyl)amino)benzoic acid (HL1) were synthesized. The characterization of newly synthesized ligand and complexes was done by 1H NMR, UV–VIS, IR, Mass spectrophotometry and molar conductivity studies. On the basis of the spectral study,…

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GRAND MULTIPARA: STILL A MAJOR RISK FACTOR?

Rita Lal, Sweta Lal, Ruchi Birendra ABSTRACT INTRODUCTION:  Multiparty has always been associated considered as a factor for poor maternal and neonatal outcome. It has often been described as a risk factor for variety of obstetric complications. Grand multipara has been defined as a parity of five or more and has been seen to have…

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