Sant Suman Rastogi, Mandavi Singh, Uttam Shrestha
ABSTRACT
Cisplatin is an anticancer drug used against various types of epithelial cancers which produces reproductive toxicity when used during pregnancy. Andrographis paniculata is a popular herb in Asia and South East Asia which is traditionally used for treatment of diabetes, hypertension and sore throat. The present study was done to observe that Andrographis paniculata may reduce Cisplatin induced reproductive toxicity in Swiss albino mice. Pregnant mice were randomly divided into four groups. Group I mice received distilled water from gestation day (GD) 10 to 17, mice in group II was intraperitoneally administered with Cisplatin on GD 10, Group III mice received Andrographis paniculata (from GD 10 to 17) and Group IV was treated with both drugs. Maternal weight of all pregnant dam was taken from GD 0 to GD18. On GD 18, experimental animals were sacrificed, fetuses were removed, weighed, CRL was measured, observed for external anomalies and preserved in 10% formalin for further studies. Cisplatin treatment significantly reduced the maternal weight gain, fetal weight and CRL whereas increased the frequency of congenital malformations in the experimental animals. These effects were reduced by treatment of Andrographis paniculata extract along with Cisplatin. Thus Andrographis paniculata proved to be beneficial in Cisplatin induced reproductive toxicity.
Key words: Kalmegh, Anticancer, Congenital malformations, Fetal weight, Maternal weight