FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF ANTIHYPERTENSIVE DRUGS ACCORDING TO BCS SYSTEM

Abhijit Sonje, Arun Yadav, A. Chandra, D. A. Jain

The main object of this study was to find out effect of two different lubricants at different concentrations (1% and 2%), of four different drugs. Four different drugs were selected according to Biopharmaceutical Classification System and their availability of antihypertensive drugs like Class 1- Propranolol Hcl, Class 2- Carvedilol, Class 3- Atenolol, and Class 4- Hydrochlorothiazide. From this study, it was revealed that, retardation of drug release increased as the concentration of lubricant increases. Sodium Stearyl Fumerate gives better result than Magnesium Stearate.   
KEYWORDS : Lubricants, Biopharmaceutical Classification System, Antihypertensive Drugs.

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