MECHANISM OF ACTION OF ANTI-DIABETIC PROPERTY OF CINNAMIC ACID, A PRINCIPAL ACTIVE INGREDIENT FROM THE BARK OF CINNAMOMUM CASSIA.

Ruchi Tandon , Anurag Gupta, Abhijit Ray

Glucose lowering potential of Cinnamon extracts is reported in a variety of studies and experimental models. Cinnamic acid is one of the main constituents, isolated from the bark of Cinnamomum cassia and is known to possess anti diabetic properties.  In the present manuscript, we are reporting  in vitro glucose uptake data using cinnamic acid, conducted in skeletal muscle cells, L6 to elicit its mechanism of action. Our studies suggest that cinnamic acid increases glucose uptake in an insulin independent manner and acts through activation of  ï¡ï€­ and  adrenoceptors in skeletal muscle cells.  
Keywords: Cinnamic acid, Glucose uptake, L6 cells,  adrenoceptors,  ï¢ adrenoceptors, AMPK.

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