Sara Abdalseed Hamed, AbdElkarim A. Abdrabo
Background: Thyroid dysfunction causes significant changes in kidney function. Both hypothyroidism and hyperthyroidism affect renal blood flow and glomerualr filteration rate (GFR). Aim: to evaluate serum creatinine, urea, and creatinine clearance concentrations in patients with thyroid dysfunctions. Materials and Methods: the study involved a control group of apparently healthy (euthyroid) (N = 90) matched for age with a test group of patients with thyroid dysfunctions (N = 96). The age range of both groups was 25-63 years. Serum creatinine, urea, and creatinine clearance concentrations were measured according to the standards. Appropriate statistical tests were used to assess significant difference in the means of the studied concentrations between patients and the control group. Results: The hypothyroid patients showed significantly higher serum creatinine (M±SD = 1.04±0.15 mg/dl), level compared with euthyroid (M±SD =0.97±0.17, P =0.033), and reduced creatinine clearance (M±SD = 93±13.6 ml/min, and 101±10.9 ml/min, respectively, P = 0.004). In hyperthyroid patients, serum creatinine concentrations were not differed (M±SD = 0.98±0.19 mg/dl) compared with the euthyroid group (M±SD = 0.97±0.17mg/dl, P = 0.16). Creatinine clearance was significantly higher in hyperthyroid compared with euthyroid (M±SD = 125±15 ml/min, and 101±10 ml/min, respectively, P = 0.006).
Blood urea concentrations were not significantly different in the studied groups
Conclusion: the study added further evidences for the possible changes that can occurs in renal functions in patients with thyroid disorders, especially GFR.