EFFECTIVENESS OF INTRAPLEURAL INSTILLATION OF MESNA FOR ADHESIOLYSIS IN MULTI LOCULATED PLEURAL EFFUSIONS, PARA PNEUMONIC EFFUSIONS AND EMPYEMA: OUR EXPERIENCE

Venkateswara Reddy Tummuru, Pradyut Waghray, A.N. V. Koteswara Rao, V Veena, Chetan Rao Vaddepally, Hasnani Rikin Bahadurbhai

ABSTRACT
Pleural effusion is abnormal accumulation of pleural fluid in pleural space. Drainage of pleural effusion is difficult in case of multiloculated effusion and multiloculated empyema. Medical thoracoscopy is indicated in cases of multiloculated pleural effusion and multiloculated empymas. We studied effectiveness of MESNA (2-mercaptoethane sulfonate Na), a chemical that breaks disulfide bond, to cause adhesiolysis and hence avoid thoracoscopy in such patients. Our study was aimed to find out the success rate of adhesiolysis in cases of multiloculated pleural effusion and multiloculated empyema.
In our study, 15 patients were studied of which 10 had multiloculated pleural effusion, and 5 had multiloculated empyema. A success rate of 90% and 40% were observed inmultiloculated effusion and multiloculated empyema respectively.

Keywords: Adhesiolysis, MESNA, Thoracoscopy, multiloculated effusion, multiloculated empyema

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