N.V. Satheesh Madhav, Deepika Raina
ABSTRACT
CNS disorders and diseases demand effectual delivery of drugs into the brain. However, transporting drugs to the brain still remains a difficult task due to the occurrence of a clenched blood-brain barrier (BBB). Many therapeutic agents may have been restrained because sufficient drug levels in the brain cannot be achieved via the systemic circulation. A non-invasive therapy would be desirable to explore alternative route of delivery to transport drugs to the brain. One of the alternative methods for brain delivery is intranasal administration. Our research work aimed to formulate bio-nano particles loaded with chlorpromazine using a novel bio-retardant from Prunus amygdalus. The bio-polymer was isolated from novel method by addition of non aqueous solvent. Five formulations were prepared using Chlorpromazine, and Prunus amygdalus as bio-polymer, and five from the synthetic polymer Pullulan gum varying concentration of bio-polymer and synthetic polymer. The nano-particles were prepared by solvent evaporation method and were evaluated for drug content entrapment efficacy in-vitro drug release in-vivo studies and stability studies.on the basis of in-vitro drug release in-vivo, pharmacokinetic data and muco adhesivity FA10(1:9) displayed the best results whose R² value was 0.9305 and hence selected as the best formulation depicted by bits software. Delivery of API molecule to the brain for the management of depressive disorder is significant, minimizes the ADR and side effects of therapeutic molecule and offer good patient compliance through this novelistic approach.
Keywords: Prunus amygdalus, Brain targeting, Chlorpromazine.