{"id":155,"date":"2012-03-15T00:00:00","date_gmt":"2012-03-15T00:00:00","guid":{"rendered":"http:\/\/npaa.in\/journal-ijta\/design-and-evaluation-of-insulin-loaded-bio-films-for-trans-soft-palatal-to-brain-delivery\/"},"modified":"2019-09-22T10:19:18","modified_gmt":"2019-09-22T10:19:18","slug":"design-and-evaluation-of-insulin-loaded-bio-films-for-trans-soft-palatal-to-brain-delivery","status":"publish","type":"post","link":"https:\/\/npaa.in\/journal-ijta\/2012\/03\/15\/design-and-evaluation-of-insulin-loaded-bio-films-for-trans-soft-palatal-to-brain-delivery\/","title":{"rendered":"DESIGN AND EVALUATION OF INSULIN LOADED BIO-FILMS FOR TRANS SOFT-PALATAL TO BRAIN DELIVERY"},"content":{"rendered":"

N.V.Satheesh Madhav, Pranshu Tangri<\/p>\n

ABSTRACT:
The current objective of our study was the formulation and evaluation of insulin loaded trans-soft palatal bio-films for treating alzhiemer\u00e2\u20ac\u2122s disease. A novel bio-film former was isolated from the fruit pulp of Artocarpus heterophyllus by our previously published method. The bio-films were aimed at delivery through the soft palate for brain targeting. The isolated bio-material was screened for filmability by forming films of the isolated bio-material by solvent casting method and mucoadhesivity by shear stress method. Six(FJ1-FJ6) formulations were prepared by varying<\/span> the polymer: drug ratios(1:1,1:2,1:3,1:4,1:5,1:6) by solvent casting method. Insulin was used as the model drug as research reveals its stimulating effect on cognition. The formulated films showed uniform surface ph, thickness, weight variation and acceptable<\/span> content uniformity, folding endurance, moisture uptake, moisture content, tensile strength. Mucoaretention studies were performed<\/span> by M.S. apparatus and Park and Robinson method. The formulation FJ3 was found to be the best formulation on the basis of mucoretention and in-vitro diffusion study. It showed mucoretention of more than 6 hours, t50% and t80% of more than 6hours and 10 hours respectively. A smart conclusion was drawn that the isolated bio-polymer can be used as an bio-film former for formulating various pharmaceutical preparations.
KEY WORDS: Artocarpus heterophyllus, insulin, bio-material, Alzheimers<\/span> disease.<\/p>\n

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N.V.Satheesh Madhav, Pranshu Tangri ABSTRACT:The current objective of our study was the formulation and evaluation of insulin loaded trans-soft palatal … <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,15],"tags":[],"class_list":["post-155","post","type-post","status-publish","format-standard","hentry","category-7","category-volume-4"],"_links":{"self":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/comments?post=155"}],"version-history":[{"count":2,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/155\/revisions"}],"predecessor-version":[{"id":832,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/155\/revisions\/832"}],"wp:attachment":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/media?parent=155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/categories?post=155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/tags?post=155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}