Rajan Shah, Smriti Karki, Niharika Shah, Sushil Dhakal, Sudhir Kumar Singh, Rajendra Kumar Chaudhari<\/p>\n\n\n\n
ABSTRACT<\/p>\n\n\n\n
Introduction: <\/strong>Carcinoma of prostate is one of the common tumors of elderly men causing significant morbidity and mortality. Other prostatic pathology ranged from inflammatory lesions to benign prostatic hyperplasia (BPH). Screening programs with prostate-specific antigen (PSA) aimed at early detection of cancer is necessary. PSA is the most useful tumors marker in diagnosis and first-line test in screening. PSA, when combined with Gleason score, improves the prediction of pathological stage for prostate carcinoma. <\/p>\n\n\n\n Objective: <\/strong>The\nobjective of this study was to investigate the relationship between serum PSA\nlevels and histological finding in biopsy of men with prostatic disease. <\/p>\n\n\n\n Materials\nand Methods: <\/strong>A hospital-based descriptive cross-sectional study over\na period of 1 year was carried out on biopsy specimen received at\nhistopathology laboratory in the department of pathology. Histopathology slides\nwere assessed and correlated with serum PSA level. <\/p>\n\n\n\n Results: <\/strong>Mean PSA\nvalue for BPH and prostatitis was 5.45 \u00b1 7.109 and 5.77 \u00b1 4.038, respectively.\nProstatic adenocarcinoma was found in about 23.3% of total biopsy specimen.\n16\/20 cases (80%) of prostate adenocarcinoma have severe elevation of serum PSA\nlevel >20 ng\/ml and majority of these cases were of high grade. Serum PSA in\nthe range of 0\u20134 ng\/ml was associated with benign lesions, and serum PSA more\nthan 20 ng\/ml was associated with malignant lesions (P <\/em><0.0001). <\/p>\n\n\n\n Conclusion:\n<\/strong>Serum PSA is elevated marginally in patients with BPH and active\ninflammation. Both benign and malignant pathologies can cause an increase in\nserum PSA levels, but the chances of finding malignancy increase with rising\nvalues of PSA. <\/p>\n\n\n\n