Parjanya Kumar Shukla, Neetu Soni, Abhinav Jha<\/p>\n
ABSTRACT
Nitrogen containing heterocycles have got special<\/span> attention in Pharmaceutical Chemistry due to their excellent<\/span> Medicinal potential<\/span>.\u00a0 The 1,2,4-triazole nucleus is associated with diverse pharmacological activities such as antibacterial, antifungal, hypoglycemic, antihypertensive, analgesic, anti-inflammatory, anti-tumor, anti-viral, urease inhibition and many other\u00a0 properties. The increasing importance of 1,2,4-Triazoles as potent biologically active agents prompted authors to synthesize new series of\u00a0 4-Amino-5-subsituted-3,4-dihydro-2H-[1,2,4]triazole-3-thiols.
Firstly\u00a0 some 4-Amino-5-subsituted-3,4-dihydro-2H-[1,2,4]triazole-3-thiol were synthesized by\u00a0 hydrazide of\u00a0 benzoic acid and its different derivatives and then\u00a0 these 1,2,4-triazole derivatives reacted with pthalic anhydride to obtain\u00a0 different 2-(5-Mercapto-3-subsituted-1,5-dihydro-[1,2,4]triazol-4-yl)-isoindole-1,3-dione. The physicochemical<\/span> properties such as physical<\/span> appearance, melting point, solubility<\/span> and spectral analysis such as 1H NMR, Mass, IR of\u00a0 synthesized compound done for structural<\/span> confirmation. Antimicrobial<\/span> activity of these synthesized compounds was carried out against several strains of bacteria and fungi by Zone diffusion method. These compounds possess good antimicrobial activity. Amikacin and fluconazole were used as standard drug for antimicrobial activity.
Key words 1,2,4-triazole, synthesis<\/span>, Antimicrobial, substitution, triazole-3-thiols<\/p>\n