{"id":184,"date":"2012-05-15T00:00:00","date_gmt":"2012-05-15T00:00:00","guid":{"rendered":"http:\/\/npaa.in\/journal-ijta\/3-hydroxy-2-substituted-phenyl-4h-chromen-4-one-derivatives-synthesis-spectral-characterization-and-pharmacological-screening\/"},"modified":"2019-09-22T10:22:14","modified_gmt":"2019-09-22T10:22:14","slug":"3-hydroxy-2-substituted-phenyl-4h-chromen-4-one-derivatives-synthesis-spectral-characterization-and-pharmacological-screening","status":"publish","type":"post","link":"https:\/\/npaa.in\/journal-ijta\/2012\/05\/15\/3-hydroxy-2-substituted-phenyl-4h-chromen-4-one-derivatives-synthesis-spectral-characterization-and-pharmacological-screening\/","title":{"rendered":"3-HYDROXY-2-(SUBSTITUTED PHENYL)-4H-CHROMEN-4-ONE DERIVATIVES- SYNTHESIS, SPECTRAL CHARACTERIZATION AND PHARMACOLOGICAL SCREENING"},"content":{"rendered":"<p>SAKSHI GUPTA, N.KUMAR, S.KUMAR, R.DUDHE, P. K. SHARMA<\/p>\n<div>A novel <span class=\"cm_word\" style=\"border-bottom: 1px solid #0000FF !important;text-decoration:underline !important;color:#0000FF !important\">series<\/span> of 3-hydroxy-2-(substituted phenyl)-4H-chromen-4-one derivatives(IIa-d) were synthesized by Algar-Flym-Oyamada reactions, o-hydroxy acetophenone and substituted aromatic aldehyde were reacted in ethanol followed by addition of sodium hydroxide (40%) which leads to the formation of substituted chalcone (Ia-d). synthesized compounds (Ia-d) were further reacted with ethanol, sodium hydroxide and hydrogen peroxide for 2-3 hours at room temperature which give the titled compound 3-hydroxy-2-(substituted phenyl)-4H-chromen-4-one(IIa-d). The structures of all these compounds have been established on the basis of analytical and <span class=\"cm_word\" style=\"border-bottom: 1px solid #0000FF !important;text-decoration:underline !important;color:#0000FF !important\">spectral<\/span> data. Synthesized compounds were characterized by their IR, <span class=\"cm_word\" style=\"border-bottom: 1px solid #0000FF !important;text-decoration:underline !important;color:#0000FF !important\">1H-NMR<\/span>, elemental and mass spectroscopic data. \u00a0Synthesized compounds were then screened for anti-oxidant, anti-inflammatory and ulcerogenic activity. The anti-oxidant activity was performed by DPPH free radical scavenging method using ascorbic acid as standard and compound IIa, IIc and IId showed significant free radical scavenging activity. The anti-inflammatory activity was performed using carrageenan induced rat paw edema method and compound IIa and IId showed most significant anti-inflammatory activity. The acute ulcerogenic activity was performed on albino-wistar rats by ceoli et al method using aspirin as standard drug. \u00a0Among the synthesized compounds only IId was found to have significant antioxidant and potential anti-inflammatory activity with no ulcerogenic effect. Among the synthesized compounds significant activity were shown by the compounds having substitution such as- 4-nitro, 3-nitro and 2, 6-dichloro respectively on the phenyl ring of the flavonol nucleus.<\/div>\n<div><span class=\"cm_word\" style=\"border-bottom: 1px solid #0000FF !important;text-decoration:underline !important;color:#0000FF !important\">Keywords<\/span>: Antioxidant, anti-inflammatory, flavonol, ulcerogenic.<\/div>\n<div><\/div>\n<p><a href=\"https:\/\/npaa.in\/journal-ijta\/admin\/ufile\/1372744186IJTA_7_1-8.pdf\">PDF<\/a><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>SAKSHI GUPTA, N.KUMAR, S.KUMAR, R.DUDHE, P. K. SHARMA A novel series of 3-hydroxy-2-(substituted phenyl)-4H-chromen-4-one derivatives(IIa-d) were synthesized by Algar-Flym-Oyamada reactions, &hellip; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,18],"tags":[],"class_list":["post-184","post","type-post","status-publish","format-standard","hentry","category-7","category-volume-7"],"_links":{"self":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/comments?post=184"}],"version-history":[{"count":2,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/184\/revisions"}],"predecessor-version":[{"id":861,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/184\/revisions\/861"}],"wp:attachment":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/media?parent=184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/categories?post=184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/tags?post=184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}