{"id":215,"date":"2012-06-01T00:00:00","date_gmt":"2012-06-01T00:00:00","guid":{"rendered":"http:\/\/npaa.in\/journal-ijta\/novel-approaches-for-insulin-delivery-current-status-2\/"},"modified":"2019-09-22T10:24:48","modified_gmt":"2019-09-22T10:24:48","slug":"novel-approaches-for-insulin-delivery-current-status-2","status":"publish","type":"post","link":"https:\/\/npaa.in\/journal-ijta\/2012\/06\/01\/novel-approaches-for-insulin-delivery-current-status-2\/","title":{"rendered":"NOVEL APPROACHES FOR INSULIN DELIVERY: CURRENT STATUS"},"content":{"rendered":"

Varshney H. M., Rajnish kumar, Shailender Mohan<\/p>\n

\u00a0Diabetes mellitus<\/span> is a serious pathologic<\/span>\u00a0condition which is responsible for major<\/span><\/div>\n
healthcare problems<\/span> worldwide and costing\u00a0billions of dollars annually. Insulin replacement<\/span><\/div>\n
therapy has been used in the clinical\u00a0management of diabetes mellitus for more than<\/span><\/div>\n
84 years.\u00a0Insulin<\/span> has remained indispensable in the\u00a0<\/span>management of diabetes mellitus since its\u00a0<\/span>discovery in 1921. Comparatively, a large\u00a0<\/span>percentage of world population is affected by<\/span><\/div>\n
diabetes mellitus, out of which approximately 5-10% with type 1 diabetes while the remaining\u00a0<\/span>90% with type 2.\u00a0<\/span>The present mode<\/span> of insulin administration is\u00a0<\/span>by the subcutaneous route through which insulin\u00a0<\/span>is introduced into the body in a non-physiological<\/span><\/div>\n
manner having many challenges<\/span>. Hence novel\u00a0approaches for insulin delivery are being<\/span><\/div>\n
explored.\u00a0Challenges that have adverse effect on oral\u00a0<\/span>route of insulin administration mainly includes:\u00a0<\/span>rapid enzymatic degradation<\/span> in the stomach,\u00a0<\/span>inactivation and digestion by proteolytic enzymes\u00a0<\/span>in the intestinal lumen and poor permeability\u00a0<\/span>across intestinal epithelium because of its high\u00a0<\/span>molecular weight and lack of lipophilicity.\u00a0<\/span>Approaches such as liposome, micro\u00a0<\/span>emulsions, nanocubicle, insulin chewing gum and\u00a0<\/span>so forth have been prepared to ensure the oral\u00a0<\/span>delivery of insulin. Attempts have been made to\u00a0<\/span>achieve oral insulin delivery using various\u00a0<\/span>systems. Scientists have been able to protect the\u00a0<\/span>insulin delivery systems from acidic environment<\/span>\u00a0<\/span>of the stomach and target it to the intestine.<\/span><\/div>\n
Limitations to the delivery of insulin have not\u00a0resulted in fruitful results to date and there is still\u00a0<\/span>a\u00a0<\/span>Keywords: Diabetes mellitus, Liposome,\u00a0<\/span>Microemulsions, Nanocubicle, Oral insulin<\/span><\/div>\n
delivery systems.<\/div>\n

PDF<\/a><\/p>\n

\u00a0<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Varshney H. M., Rajnish kumar, Shailender Mohan \u00a0Diabetes mellitus is a serious pathologic\u00a0condition which is responsible for major healthcare problems … <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,18],"tags":[],"class_list":["post-215","post","type-post","status-publish","format-standard","hentry","category-7","category-volume-7"],"_links":{"self":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/comments?post=215"}],"version-history":[{"count":3,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/215\/revisions"}],"predecessor-version":[{"id":892,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/215\/revisions\/892"}],"wp:attachment":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/media?parent=215"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/categories?post=215"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/tags?post=215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}