{"id":245,"date":"2013-11-27T00:00:00","date_gmt":"2013-11-27T00:00:00","guid":{"rendered":"http:\/\/npaa.in\/journal-ijta\/hepatotoxic-changes-induced-by-prenatal-administration-of-zidovudine-in-swiss-albino-mice\/"},"modified":"2019-09-22T10:33:25","modified_gmt":"2019-09-22T10:33:25","slug":"hepatotoxic-changes-induced-by-prenatal-administration-of-zidovudine-in-swiss-albino-mice","status":"publish","type":"post","link":"https:\/\/npaa.in\/journal-ijta\/2013\/11\/27\/hepatotoxic-changes-induced-by-prenatal-administration-of-zidovudine-in-swiss-albino-mice\/","title":{"rendered":"HEPATOTOXIC CHANGES INDUCED BY PRENATAL ADMINISTRATION OF ZIDOVUDINE IN SWISS ALBINO MICE"},"content":{"rendered":"<p>Amit Nayak, Mandavi Singh and Anand Mishra<\/p>\n<div style=\"text-align: justify;\">ABSTRACT<\/div>\n<div style=\"text-align: justify;\">Introduction \u00e2\u20ac\u201c Zidovudine is the first anti retroviral agent approved by FDA for treatment of HIV. Now a day it is used along with other anti retro viral agents to prevent maternal to child transmission. But its safety margin is yet to be ascertained.<\/div>\n<div style=\"text-align: justify;\">Materials and methods \u00e2\u20ac\u201c Pregnant albino mice was given zidovudine in the dose of 50mg\/kg, 100mg\/kg, 50mg\/kg by oral gavage from 6th -16th day of gestation and control mice was fed distilled water during the same period. On day 17th maternal blood was collected for liver function test. On day 19th the mice was sacrificed and foetuses were taken out .The liver of foetuses were dissected, formalin fixed, processed and stained with H&#038;E and PAS for histological study.<\/div>\n<div style=\"text-align: justify;\">Results- The treated foetal liver shows fatty degeneration, hepatocytic degradation and loss of cytoarchitecture in a dose dependent manner. The serum bilirubin and transaminases were increased and serum albumin was decrease in dams denoting toxic effect of this drug on the mother.\u00a0<\/div>\n<div style=\"text-align: justify;\">Conclusion- Zidovudine causes hepatoitoxicity in both mother and fetus if given to mother during pregnancy and should be used with caution in pregnancy.<\/div>\n<div style=\"text-align: justify;\"><\/div>\n<p><a href=\"https:\/\/npaa.in\/journal-ijta\/admin\/ufile\/1385569611IJTA_13_20-23.pdf\">PDF<\/a><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amit Nayak, Mandavi Singh and Anand Mishra ABSTRACT Introduction \u00e2\u20ac\u201c Zidovudine is the first anti retroviral agent approved by FDA &hellip; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,24],"tags":[],"class_list":["post-245","post","type-post","status-publish","format-standard","hentry","category-10","category-volume-13"],"_links":{"self":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/comments?post=245"}],"version-history":[{"count":2,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/245\/revisions"}],"predecessor-version":[{"id":922,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/245\/revisions\/922"}],"wp:attachment":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/media?parent=245"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/categories?post=245"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/tags?post=245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}