{"id":249,"date":"2013-12-09T00:00:00","date_gmt":"2013-12-09T00:00:00","guid":{"rendered":"http:\/\/npaa.in\/journal-ijta\/development-and-evaluation-of-anti-diabetic-polyherbal-formulation-on-alloxan-induced-rats\/"},"modified":"2019-09-22T10:33:49","modified_gmt":"2019-09-22T10:33:49","slug":"development-and-evaluation-of-anti-diabetic-polyherbal-formulation-on-alloxan-induced-rats","status":"publish","type":"post","link":"https:\/\/npaa.in\/journal-ijta\/2013\/12\/09\/development-and-evaluation-of-anti-diabetic-polyherbal-formulation-on-alloxan-induced-rats\/","title":{"rendered":"DEVELOPMENT AND EVALUATION OF ANTI-DIABETIC POLYHERBAL FORMULATION ON ALLOXAN INDUCED RATS"},"content":{"rendered":"<p>Rajput Rekha, Chandra Amrish<\/p>\n<div style=\"text-align: justify;\">The polyherbal anti-diabetic formulation is prepared in suspension form by mixing the petroleum ether and chloroform extracts of five medicinal plants which are indigenous in India with other excipients because plants are a potential source of anti-diabetic drugs. The anti-diabetic effect of prepared suspension was evaluated at two different doses which were decided by acute toxicity studies by using OECD (Organization for Economic Co-operation and Development) guideline 420.The results of acute toxicity study was revealed that there was no mortality observed at 2000mg\/kg for the formulation in mice. Therefore 2000mg\/kg dose was considered as cutoff dose so 1\/10th and 1\/5th of maximum dose was selected i.e.200mg\/kg and 400mg\/kg, for anti-diabetic studies. It was found that the anti-diabetic activity of formulation in suspension form at a dose of 400mg\/kg of body weight (253.33\u00c2\u00b1 0.71) more effective than 200mg\/kg of body weight (283.33 \u00c2\u00b10.49) on wistar albino rats. It was also showed that the anti-diabetic activity of polyherbal formulation in suspension \u00a0form is nearly comparable with standard drug glibenclamide (261.5 \u00c2\u00b10.56) and the formulation at the dose of 200mg\/kg was showed more significant anti-diabetic effect at 1st hour(336.5\u00c2\u00b1 0.76) after single dose drug administration than \u00a0400mg\/kg body weight but the formulation at dose of 400mg\/kg was also showed more significant effect at 4th \u00a0 hours(304.16\u00c2\u00b1 1.01) when its compare with the standard \u00a0group ( 302.33\u00c2\u00b10.88) on wistar albino rats and continue this significant effect till 24th hours. So it was \u00a0concluded that the \u00a0formulation have significant anti-diabetic activity and also stable till the 3 month which was observed by the stability testing by using different parameters used for evaluation of suspension.<\/div>\n<div style=\"text-align: justify;\">Key words: Polyherbal formulation, Glibenclamide, Suspension<\/div>\n<p><a href=\"https:\/\/npaa.in\/journal-ijta\/admin\/ufile\/1386571157IJTA_13_30-35.pdf\">PDF<\/a><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rajput Rekha, Chandra Amrish The polyherbal anti-diabetic formulation is prepared in suspension form by mixing the petroleum ether and chloroform &hellip; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,24],"tags":[],"class_list":["post-249","post","type-post","status-publish","format-standard","hentry","category-10","category-volume-13"],"_links":{"self":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/249","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/comments?post=249"}],"version-history":[{"count":2,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/249\/revisions"}],"predecessor-version":[{"id":926,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/249\/revisions\/926"}],"wp:attachment":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/media?parent=249"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/categories?post=249"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/tags?post=249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}