{"id":411,"date":"2015-12-24T00:00:00","date_gmt":"2015-12-24T00:00:00","guid":{"rendered":"http:\/\/npaa.in\/journal-ijta\/impaired-glucose-tolerance-test-in-blood-transfusion-dependent-beta-thalassemic-children\/"},"modified":"2019-09-22T11:03:56","modified_gmt":"2019-09-22T11:03:56","slug":"impaired-glucose-tolerance-test-in-blood-transfusion-dependent-beta-thalassemic-children","status":"publish","type":"post","link":"https:\/\/npaa.in\/journal-ijta\/2015\/12\/24\/impaired-glucose-tolerance-test-in-blood-transfusion-dependent-beta-thalassemic-children\/","title":{"rendered":"IMPAIRED GLUCOSE TOLERANCE TEST IN BLOOD TRANSFUSION DEPENDENT BETA THALASSEMIC CHILDREN"},"content":{"rendered":"<p>Bablu Kumar Gaur, Sunita Koreti, G.Das<\/p>\n<div style=\"text-align: justify; \">ABSTRACT<\/div>\n<div style=\"text-align: justify; \">Impaired glucose tolerance and Serum ferritin level in transfusion-dependent \u00ce\u00b2-thalassemic children was studied. Known case of beta Thalassemia major childrens being regularly transfused in Department of Pediatrics, Kamla Raja Hospital, Gwalior.\u00a0<\/div>\n<div style=\"text-align: justify; \">This study was done on 60 children between 3-17 years of age with \u00ce\u00b2 thalassemia major. Information regarding name, age, sex, height, body weight, age at the first blood transfusion, frequency of blood transfusion per year, age at the start of iron-chelation therapy, compliance with chelation therapy, H\/O Diabetes mellitus and history of previous splenectomy was taken. For each patient glucose tolerance test was performed and S.ferritin levels were \u00a0measured.<\/div>\n<div style=\"text-align: justify; \">The prevalence of impaired glucose tolerance was 20%, the Serum ferritin was highly \u00a0raised in all \u00a0thalassaemic children, with highly statistical significant differences between normal and impaired GTT patients.(p.value<0.001) Mean serum ferritin was found to be 2089 \u00c2\u00b1 690 \u00ce\u00bcg\/l in patients with normal GTT while it was 4100 \u00c2\u00b1 518 \u00ce\u00bcg\/l in Impaired GTT. Significant variation was found (p value<0.05) in children with impaired glucose tolerance compared to normal glucose tolerance with respect to age, age of first blood transfusion, age of starting chelation therapy. Patients with impaired glucose tolerance had a mean transfusions of 137.58\u00c2\u00b120.15 times while those with normal glucose tolerance had 58.85\u00c2\u00b139.80 times of transfusions (p.value<0.001).\u00a0<\/div>\n<div style=\"text-align: justify; \">Most of patients with impaired glucose tolerance in present study had received more then 100 blood transfusion and serum ferritin level >3000\u00ce\u00bcg\/L with mean age of 13.0 years indicating that abnormal glucose homeostasis begin after 10 year of age.<\/div>\n<div style=\"text-align: justify; \"><\/div>\n<div style=\"text-align: justify; \"><b>Keywords:<\/b> beta-Thalassemia major, impaired glucose tolerance, Serum ferritin,chelation therapy.<\/div>\n<p><a href=\"https:\/\/npaa.in\/journal-ijta\/admin\/ufile\/1451839114IJTA_30_1-6.pdf\">PDF<\/a><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bablu Kumar Gaur, Sunita Koreti, G.Das ABSTRACT Impaired glucose tolerance and Serum ferritin level in transfusion-dependent \u00ce\u00b2-thalassemic children was studied. &hellip; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,44],"tags":[],"class_list":["post-411","post","type-post","status-publish","format-standard","hentry","category-12","category-volume-30"],"_links":{"self":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/411","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/comments?post=411"}],"version-history":[{"count":2,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/411\/revisions"}],"predecessor-version":[{"id":1088,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/posts\/411\/revisions\/1088"}],"wp:attachment":[{"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/media?parent=411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/categories?post=411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/npaa.in\/journal-ijta\/wp-json\/wp\/v2\/tags?post=411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}