Parjanya Kumar Shukla, Neetu Soni, Abhinav Jha
ABSTRACT
Nitrogen containing heterocycles have got special attention in Pharmaceutical Chemistry due to their excellent Medicinal potential. The 1,2,4-triazole nucleus is associated with diverse pharmacological activities such as antibacterial, antifungal, hypoglycemic, antihypertensive, analgesic, anti-inflammatory, anti-tumor, anti-viral, urease inhibition and many other properties. The increasing importance of 1,2,4-Triazoles as potent biologically active agents prompted authors to synthesize new series of 4-Amino-5-subsituted-3,4-dihydro-2H-[1,2,4]triazole-3-thiols.
Firstly some 4-Amino-5-subsituted-3,4-dihydro-2H-[1,2,4]triazole-3-thiol were synthesized by hydrazide of benzoic acid and its different derivatives and then these 1,2,4-triazole derivatives reacted with pthalic anhydride to obtain different 2-(5-Mercapto-3-subsituted-1,5-dihydro-[1,2,4]triazol-4-yl)-isoindole-1,3-dione. The physicochemical properties such as physical appearance, melting point, solubility and spectral analysis such as 1H NMR, Mass, IR of synthesized compound done for structural confirmation. Antimicrobial activity of these synthesized compounds was carried out against several strains of bacteria and fungi by Zone diffusion method. These compounds possess good antimicrobial activity. Amikacin and fluconazole were used as standard drug for antimicrobial activity.
Key words 1,2,4-triazole, synthesis, Antimicrobial, substitution, triazole-3-thiols