S.Chandra, S. Gautam, A. Kumar, S.Agrawal
ABSTRACT
Complexes of Mn(II), and Ni(II) were synthesized with polydentate ligand i.e. isophthalicacid-bis(thiosemicabazone) by using condensation reaction. The polydentate ligand was synthesized by the reaction of isophthalic acid and thiosemicabazide in 1:2 ratio in alcoholic medium. Synthesized ligand was characterized by melting point, elemental analysis, infra-red, 1H-NMR, mass, electronic spectra, and molecular modeling. Metal complexes of synthesized ligand were characterized by melting point, elemental analysis, molar conductance, magnetic moment, infra-red, uv-visible, electron paramagnetic resonance, and molecular modeling. On the basis of elemental analysis metal complexes possessed the general composition M(L)X2 where M = Mn(II), Ni(II) L = ligand, X = Cl-, CH3COO-(OAc), NO3-. The IR data indicated that the ligand coordinated to metal ion through nitrogen and sulphur donor atoms. The spectral studies revealed that all complexes possessed monomeric composition. On the basis of spectral studies, complexes were found to have six coordinated octahedral geometry. The ligand field parameters were calculated using various energy level diagrams. In vitro ligand and metal complexes were examined against some pathogenic fungi to assess their mycological activity.
Keywords: polydentate ligand, Mn(II), Ni(II) complexes, electron paramagnetic resonance, molecular modeling, mycological activity